ea0016p336 | Endocrine tumours | ECE2008
Buch Thomas
, Grzelinski Marius
, Pinkenburg Olaf
, Gold Maike
, Aigner Achim
, Gudermann Thomas
The malignant phenotype of small cell lung cancer (SCLC) cells critically relies on the autocrine stimulation of G12/13- and Gq/11-coupled neuropeptide receptors. By this means, G12/13- and Gq/11-dependent signalling pathways are constitutively activated in these cells. While Gq/11-dependent signalling has been shown to promote proliferation of SCLC cells, the role of signalling pathways via G12/13 is still elus...